Effect of complement 5a receptor (C5R1) deficiency on liver fibrosis in mice
K Hochrath, SN Weber, S Hillebrandt, U Pieper-Fürst, V Schmitz, S Huss, HP Fischer · Zeitschrift für Gastroenterologie · 2011 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background: Previously we refined a quantitative trait locus that confers susceptibility to hepatic fibrosis in inbred mice and showed, that the gene encoding complement factor C5 underlies this fibrogenic locus in mice (Nat Genet 2005). C5R1 is a G protein-coupled receptor that specifically binds C5a, the potent proinflammatory fragment of C5. Our aim now was to dissect whether the profibrogenic effects of C5 are mediated via C5R1. Methods: We analysed C5R1 knockout mice (C5R1-/- ) and C57BL/6J wild-type controls (N=10 per genotype) after fibrosis induction by CCl4 (12 x i.p., 0.7mg/kg). Liver enzyme activities…
