Thrombophilic genetic polymorphisms and placental histomorphology in pregnancies conceived by assisted reproductive technology

Inherited thrombophilia is a condition that predisposes individuals to thrombosis and thromboembolism particularly during pregnancy. Infarction of maternal placental surface (MFI) and massive perivillous fibrin deposition (MPVFD) represents specific placental lesions associated with recurrent adverse fetal outcomes and maternal thrombophilic condition. The aim of this study was to evaluate an association between common thrombophilic genetic mutations and specific placental lesions in pregnancies conceived by assisted reproductive technology. We studied incidence of maternal thrombophilias (factor V Leiden (FVL),…