Placenta-derived Mesenchymal Stem Cells for the Neuroregeneration in a Rat Perinatal Brain Injury Model
M Müller, A Schoeberlein, U Reinhart, R Sager, M Messerli, D Surbek · Zeitschrift für Geburtshilfe und Neonatologie · 2011 · Heft 11
Bibliografische Angaben
Zusammenfassung
Aim: Perinatal brain injury in the premature infant often leads to severe longterm disability. Stem cell transplantation has been proposed as a therapy for neurodegenerative diseases.The aim of this study is to assess the therapeutic potential of stem cell transplantation in an animal model of peripartal brain damage. Perinatal brain injury model: Perinatal brain injury was induced in newborn (postnatal days 2–7) Wistar rats by the following procedure (Fig. 1). Stem cell transplantation: Injured and sham-treated animals were transplanted 24h, 1 week or 4 week post injury using a stereotaxic frame. Mesenchymal st…
