Quantification of cerebral hemodynamics in patients with multiple sclerosis: dynamic contrast-enhanced MRI in 3D at 3T
M Ingrisch, F Schwab, S Sourbron, T Kümpfel, R Hohlfeld, M Reiser, B Ertl-Wagner · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2011 · Heft 12
Bibliografische Angaben
Zusammenfassung
Purpose: The quantification of cerebral hemodynamics, comprised of cerebral blood flow (CBF), cerebral blood volume (CBV) and permeability-surface area product (PS) as a measure of blood-brain barrier permeability in MS lesions in the brain is challenging. With conventional dynamic susceptibility weighted MRI, several issues with quantification arise, in particular in areas with blood-brain barrier disruption. In this study, we investigate the feasibility of a rapid 3D T1-weighted dynamic contrast-enhanced (DCE) MRI measurement, providing coverage of the entire neurocranium, in combination with a two-compartment…