CareLit Fachartikel
Essential role of Sharpin in TNFα dependent NFκB activation in primary hepatocytes
N Lange, S Sieber, A Erhardt, G Sass, HJ Kreienkamp, G Tiegs · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
1170837
CareLit-ID
Jahr
2012
Publikation
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Zusammenfassung
Backgrounds&aims: Tumour necrosis factor (TNF)-α triggers cell survival and apoptosis in hepatocytes. The cell survival pathway depends on post-translational modifications (PTM) leading to activation of NFκB. An essential PTM is ubiquitination that regulates NFκB activation at different steps. One important ubiquitination step depends on the linear ubiquitin chain assembly complex (LUBAC) that is responsible for ubiquitination of IKKγ (NEMO). As recently shown, LUBAC consists of HOIP, HOIL–1L and Sharpin. We analysed TNFα dependent NFκB activation in Sharpin-deficient primary hepatocytes (PH). Methods: Using Sha…
Schlagworte
LUBAC
NFκB pathway
Sharpin
TNFα
ubiquitination
Apoptosis
Caspase 3
Bacterial Toxins
Caspase 8
Antigens
Zeitschrift für Gastroenterologie
