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Hepatic cytochrome P–4502E1 induction correlates significantly with the degree of steatosis, inflammation, fibrosis and exocyclic etheno DNA-adducts in patients with alcoholic ste…

Q Hua, K Glassen, R Waldherr, G Millonig, S Mueller, HK Seitz · Zeitschrift für Gastroenterologie · 2012 · Heft 01

Dokument
1170839
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
Q Hua, K Glassen, R Waldherr, G Millonig, S Mueller, HK Seitz
Ausgabe
Heft 01 / 2012
Seiten
–
Erschienen: 2012-01-09 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0031-1295749

Zusammenfassung

It has been shown that cytochrome P402E1 (CYP2E1) is induced in alcoholic liver disease (ALD)1 and in non-alcoholic fatty liver disease (NAFLD)2. Hepatic CYP2E1 is responsible for the generation of reactive oxygen species (ROS) which may stimulate fibrogenesis and carcinogenesis since hepatic CYP2E1 correlates significantly with highly carcinogenic exocyclic etheno DNA-adducts (edA) 3. In experimental ALD inhibition of CYP2E1 by chlormethiazole (CMZ), a strong CYP2E1 inhibitor prevents ALD partially4 and inhibits carcinogenesis. The purpose of this study was to further investigate the role of CYP2E1 in patients…

Schlagworte

4HNE ALD CYP2E1 Cytochrome Reactive Oxygen Species Chlormethiazole Zeitschrift für Gastroenterologie