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Hepcidin knockout mice as a model of iron-overload associated liver fibrosis development

M Lunova, S Vaulont, J Haybaeck, K Lackner, P Strnad · Zeitschrift für Gastroenterologie · 2012 · Heft 01

Dokument
1170840
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
M Lunova, S Vaulont, J Haybaeck, K Lackner, P Strnad
Ausgabe
Heft 01 / 2012
Seiten
–
Erschienen: 2012-01-09 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0031-1295759

Zusammenfassung

Background and aims: Hepcidin is the central regulator of iron homeostasis. Disrupted hepcidin signalling results in hereditary hemochromatosis and iron overload in chronic liver disorders. While the association between iron overload and development of end-stage liver disease is well established, the understanding of the underlying pathomechanisms is hampered by the lack of a suitable animal model. To circumvent this problem, we studied hepcidin-knockout (KO) mice as a model of iron-overload associated liver disease. Methods: 6 and 12 month-old hepcidin-KO and -wild type (WT) mice fed 3% iron carbonyl-containing…

Schlagworte

Diet Association Absorption Apoptosis Actin Zeitschrift für Gastroenterologie