CareLit Fachartikel

Human augmenter of liver regeneration could have a potential protective role in an alcohol-induced toxicity model

C Schelcher, S Lee, C Casey, S Gashi, KW Jauch, WE Thasler · Zeitschrift für Gastroenterologie · 2012 · Heft 01

Dokument
1170842
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
C Schelcher, S Lee, C Casey, S Gashi, KW Jauch, WE Thasler
Ausgabe
Heft 01 / 2012
Seiten
–
Erschienen: 2012-01-09 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0031-1295779

Zusammenfassung

Background Alcoholic liver disease (ALD) is a major health problem worldwide and development of a therapeutical agent that could enhance protection against apoptosis would facilitate the treatment of ALD. The augmenter of liver regeneration (ALR) was originally discovered as a key protein in liver regeneration and more recently studies have found that ALR also protects against cell death caused by various apoptotic stimuli. ALR has two isoforms; the full-length isoform (fALR) is localised in the inter-membrane space of the mitochondrion, while the truncated isoform (tALR) is a circulating cytokine. However, the…

Schlagworte

ALR Alcoholic liver disease Augmenter of liver regeneration Liver regeneration apoptosis Alanine Transaminase Cytokine Alanine Blood Diet After Zeitschrift für Gastroenterologie