CareLit Fachartikel

Xanthohumol suppresses hepatic inflammatory response to warm ischemia-reperfusion injury

C Dorn, J Heilmann, C Hellerbrand · Zeitschrift für Gastroenterologie · 2012 · Heft 01

Dokument
1170848
CareLit-ID
Jahr
2012
Publikation
PDF
nein
Metadaten
DOI
ja
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
C Dorn, J Heilmann, C Hellerbrand
Ausgabe
Heft 01 / 2012
Seiten
–
Erschienen: 2012-01-09 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0031-1295849

Zusammenfassung

Liver ischemia/reperfusion (I/R) leads to the formation of reactive oxygen species (ROS), which cause liver injury and initiate an inflammatory response, a critical problem after liver surgery and transplantation. Xanthohumol, the major prenylated chalcone found in hops, is known for its anti-inflammatory and ROS-scavenging properties. The aim of this study was to investigate the effect of xanthohumol in a model of warm ischemia-reperfusion liver injury. Methods and Results: Xanthohumol was applied to BALB/c mice orally at a dose of 1mg/g body weight for 5 days before warm ischemia/reperfusion (I/R) injury was i…

Schlagworte

After Transplantation Reactive Oxygen Species Cytokines Chalcone Blood Diet Zeitschrift für Gastroenterologie