CareLit Fachartikel
Toll-like receptor-activated primary human hepatocytes produce inflammatory cytokines and different types of interferon, resulting in HCV suppression in vitro
R Bröring, M Lutterbeck, K Kleinehr, A Paul, G Gerken, JF Schlaak · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
1170853
CareLit-ID
Jahr
2012
Publikation
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zitierfähig
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Zusammenfassung
Aims: The function of the hepatic innate immune system and its role in the defence against Hepatitis C Virus infection is not well understood. Recent publications suggested that type-III interferons (IFN; Interleukin 28A, –28B and –29) play a crucial role in the host response against HCV. Aim of this study was to investigate the Toll-like receptor (TLR) signaling in primary human hepatocytes and the capacity of these cells to produce type-III IFNs and their ability to control HCV replication. Methods: Human liver samples were obtained after tumor resection (n=16) or liver transplantation (n=14). Human hepatocyte…
Schlagworte
Interferon
Toll-like receptor
human hepatocytes
After
Cytokines
Tumor
Transplantation
Hepatitis
Zeitschrift für Gastroenterologie
