Telbivudine treatment improves renal function of Chronic Hepatitis B (CHB) patients
E Gane, G Deray, T Piratvisuth, HLY Chan, J Jia, H Ren, J Rasenack, M Manns, D Amarapurkar, Y Dong, A Trylesinski · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Complications of CHB including cirrhosis result in nearly 1 million deaths annually. Renal dysfunction is common in decompensated CHB cirrhosis and is associated with high mortality. Nucleot(s)ide treatment improves liver function and survival. Renal dysfunction can reduce clearance of nucleot(s)ides increasing drug-associated toxicities resulting with high mortality. Recently, study on decompensated CHB patients showed significantly improvement of GFR for those receiving telbivudine in comparison to patients under lamivudine. We assessed GFR in compensated CHB patients included in several pivotal telbivudine (L…
