CareLit Fachartikel

Selective induction of apoptosis by HMG-CoA-reductase inhibitors in hepatoma cells is dependent on p53 expression

J Kah, A Wüstenberg, A Keller, H Sirma, G Tiegs, G Sass, M Dandri · Zeitschrift für Gastroenterologie · 2012 · Heft 01

Dokument
1170861
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
J Kah, A Wüstenberg, A Keller, H Sirma, G Tiegs, G Sass, M Dandri
Ausgabe
Heft 01 / 2012
Seiten
–
Erschienen: 2012-01-09 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0031-1295979

Zusammenfassung

Background and Aims: HMG-CoA-reductase-inhibitors (statins) are widely used drugs to interfere with cholesterol biosynthesis. Besides this usage, evidence increases that statins might also be useful in therapy of viral infections or cancer. We investigated the effects of statins on primary mouse and human hepatocytes as well as mouse (Hepa1–6) and human (Huh7, HepG2, Hep3B) hepatoma cell lines. Methods: Effects of fluva-, simva-, atorva-, rosuva-, prava- and lovastatin on viability of primary mouse and human hepatocytes as well as mouse (Hepa1–6) and human (Huh7, HepG2, Hep3B) hepatoma cell lines were measured b…

Schlagworte

Targeted therapy apoptose statins Tumor Cholesterol Apoptosis Zeitschrift für Gastroenterologie