A nuclear pore component regulates select p53 target genes
SR Singer, A Barsotti, M Fazollahi, A Ouwehand, D Grünwald, K Breuhahn, H Bussemaker, R Singer, P Schirmacher, C Prives · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Alhough many studies have focused on specific transcriptional programs regulated by p53 in response to different stresses, p53 target gene preference is still poorly defined and may rely on additional modes of regulation. Here, we demonstrate that the nucleoporin Nup98 is required for full expression of key effectors of the p53 pathway, such as p21, by a process that occurs post-transcriptionally. Nup98 associates with the 3’-UTR of p21 mRNA and protects it from degradation by the exosome. An in silico approach reveals that also other p53 target genes (e.g. 14–3–3 sigma) are similarly regulated by Nup98. Express…
