CareLit Fachartikel
Permeabilization of the Tight Junction: A Perspective for Tissue-Specific Drug Targeting
Salah Amasheh, Rita Rosenthal, Jörg-Dieter Schulzke, Michael Fromm · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
1171016
CareLit-ID
Jahr
2012
Publikation
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
Abstract Epithelial barrier properties are determined by three components, namely transcellular permeability, the paracellular pathway, and locally limited peaks of permeability caused by apoptoses. Whereas transcellular permeability is strongly dependent on polarity or specific substrate recognition by membrane receptors and transport proteins, a promising target for specific permeabilization is the tight junction. Within this structure, tetraspan tight junction proteins have been shown to determine paracellular barrier properties, including occludin, tricellulin and the family of claudins. Especially members o…
Schlagworte
Claudins
Absorption
Clostridium perfringens
Blood-Brain Barrier
Clostridium
Claudin-1
Claudin-2
Blood
Caco-2 Cells
Actomyosin
Claudin-3
Claudin-5
Adherens Junctions
Drug Development
Ampicillin
Antigens
