Moving Hands or Moving Feet: Cortical Connectivity during isolated limb movements

Introduction: Any motor action results from dynamic interactions of various brain regions involved in the various aspects of movement preparation and execution. The most important cortical motor output is provided by the primary motor cortex (M1) in which foot movements are represented on the mesial surface whereas hand movements are generated on the lateral surface at the "hand knob" formation. We here used fMRI and dynamic causal modelling (DCM) to investigate effective connectivity in the cortical motor system during voluntary movements of the hands and feet. Methods: 13 healthy right-handed subjects were sca…