CareLit Fachartikel

Alternative tumor suppressor mechanisms in lung carcinomas – modulation of senescence by growth factor-induced signaling

B Markova, F Breitenbücher, M Schuler · Pneumologie · 2012 · Heft 02

Dokument
1171095
CareLit-ID
Jahr
2012
Publikation
PDF
nein
Metadaten
DOI
ja
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
B Markova, F Breitenbücher, M Schuler
Ausgabe
Heft 02 / 2012
Seiten
–
Erschienen: 2012-02-23 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0032-1302889

Zusammenfassung

Oncogene- induced senescence (irreversible cell cycle arrest) is recognized as an important tumor-suppressive mechanism, bypassing of which may contribute to malignant transformation of the cells. On the other hand, senescence induction, in addition to apoptosis stimulation and proliferation suppression, is responsible for the cytostatic activity of many commonly used anticancer drugs. Therefore, senescence escape must be considered as an important drug-resistance factor. In our work we characterize „DNA Damage Response“(DDR)-independent senescence caused by tyrosine kinase inhibitors (TKI) and growth factors de…

Schlagworte

Tumor Drug Resistance Association Apoptosis Lead Work Pneumologie