Molecular analysis of cell-free DNA using SHO mouse/HT-29 colorectal adenocarcinoma cell line xenograft model
B Barták, Z Nagy, S Spisák, F Sipos, G Valcz, A Kalmár, VÁ Patai, K Tóth, B Wichmann, A Schöller, K Leiszter, B Molnár, Z Tulassay · Zeitschrift für Gastroenterologie · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: Cell-free DNA (cfDNA) was first detected in human plasma in the 1940s, but the knowledge on its origin, regulation and rate of release is incomplete. In many cancer patients increased cfDNA concentration was measured compared to healthy control, that originates from both normal and tumor cells. The release of cfDNA from cancer cells can be a consequence of various physiological events such as apoptosis, necrosis and direct secretion. Aims: Our primary aim was to investigate the rate of cfDNA's release using SHO mouse/HT-29 colorectal adenocarcinoma cell line xenograft model. Our further aim was to…
