Revisiting predictors of sustained virologic response in HIV/HCV coinfected patients treated with Pegifn+RBV: GGT and LDL may play a role
M Mandorfer, T Reiberger, BA Payer, A Ferlitsch, F Breitenecker, MC Aichelburg, B Obermayer-Pietsch, A Rieger, M Trauner, M Peck-Radosavljevic · Zeitschrift für Gastroenterologie · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aims: Much debate remains regarding predictors of sustained virologic response (SVR) in HIV/HCV coinfected patients treated with pegylated interferon and ribavirin (PEGIFN+RBV). Apart from established predictors, such as HCV-Genotype (HCV-GT), IL-28B single nucleotide polymorphism (SNP), and liver fibrosis, insulin resistance (IR) and LDL have also been proposed as predictors of SVR. GGT has been shown to be a predictor of SVR in HCV monoinfected patients. Methods: Histological METAVIR liver fibrosis stage, HCV-RNA levels, HCV-GT, IL28B SNP, GGT, LDL, fasting insulin and glucose levels, as well as CD4+ cell coun…
