CareLit Fachartikel
Sfrp5 serum concentration is associated with measures of glucose homeostasis and insulin sensitivity in human obesity
G Flehmig, M Fasshauer, N Klöting, MR Schön, M Stumvoll, M Blüher · Diabetologie und Stoffwechsel · 2012 · Heft 05
Dokument
1171474
CareLit-ID
Jahr
2012
Publikation
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Metadaten
DOI
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Zusammenfassung
Background and aims: Secreted frizzled-related protein-5 (SFRP5) has been identified to antagonize Wnt signalling as a central pathway of adipogenesis which is related to metabolic disorders. Mice with a disruption of SFRP5 have elevated fasting glucose and insulin levels upon high fat and high-sucrose diet. SFRP5 expression in mature adipocytes correlates with increasing adiposity. Materials and methods: We investigated SFRP5 serum concentration in a cross-sectional study of 213 individuals with a wide range of age, BMI, body fat mass, and measures of glucose metabolism and insulin sensitivity. In addition, cir…
Schlagworte
Diet
After
Bariatric Surgery
Adipogenesis
Adipocytes
Creatinin
Obesity
Diabetologie und Stoffwechsel
