CareLit Fachartikel
Nontypeable Haemophilus influenzae activates the NLRP3 inflammasome and leads to Caspase-1 dependent secretion of IL-1beta – a possible pathway of exacerbations in COPD
K Rohmann, J Rotta detto Loria, D Droemann, J Rupp, T Goldmann, K Dalhoff · Pneumologie · 2012 · Heft 05
Dokument
1171535
CareLit-ID
Jahr
2012
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
The inflammasome is a cytosolic protein complex important for early inflammatory responses of the innate immunity. Inflammasome activation has been described for several types of infection, and our data indicate that also nontypeable Haemophilus influenzae (NTHi) induces the assembly of the inflammasome components. The inflammasome consists of NOD-like receptors such as NLRP3, the adaptor protein ASC and Caspase-1 which cleaves pro-IL-1β into its active form. Murine macrophages (RAW 264.7) and human lung tissue were stimulated with NTHi 106cfu/ml for 24–48h. Supernatants and cells were collected to measure the i…
Schlagworte
Caspase 1
Actin
After
Respiratory Tract Infections
Cytokine
Pneumologie
