Autophagy response against protection and pathology; balance for better or for worse in Cystic Fibrosis

Introduction: Cystic fibrosis (CF) patients are commonly associated with increased bacterial infection of the airways usually with P. aeruginosa and S. aureus leading to increased mortality and morbidity. However, reduced innate immune responses were reported. The underlying molecular details linking protection against immunity and destructive pathology in CF are becoming more interesting. It is most likely that during infection, there is a crosstalk between the interaction of TLR4 with pathogen-associated molecular patterns and the immune cells thereby activating the anti-inflammatory pathways and cytoprotectiv…