The role of NFκB/IKK2 pathway in the pathogenesis of lung cancer

The nuclear factor κB (NF-κB) comprises a family of transcription factors involved in many physiological processes such as innate and adaptive immune responses, cell proliferation, cell death, and inflammation. The dimeric NFκB transcription factors are inhibited in quiescent cells through stable association with inhibitor IκBs. Recent literature suggests aberrant or constitutive NF-κB activation in many human malignancies, including lung cancer. Hence, we aim to decipher the role of NF-κB on tumour progression and metastasis employing a non-metastatic tumour animal model, SPC-CRaf-BXB. We generated SPC-CRaf BXB…