Role of the endothelial receptor neuropilin-1 in the modulation of VEGF effects in the vascular system
L Mey, Z Kharip, M Hörmann, A Hildenberg, C Löwer, R Kinscherf, M Gassmann, T Gerriets, N Al-Fakhri · Pneumologie · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: Vascular endothelial growth factor (VEGF) inhibits apoptosis in vascular endohelial cells (EC) via VEGF-R2, JNK and Akt by regulating poly(ADP-ribose)-polymerase (PARP), as we have previously demonstrated. The aim of this study was to analyze the influence of neuropilin-1 (NP-1), a coreceptor of VEGF-R2, on VEGF effects during apoptosis induction in EC cultures and in an animal model of endothelial apoptosis. Methods: HUVEC and the EC-line EA.hy.926 were incubated with VEGF-A(165) or VEGF-A(121), with the inhibitors SU5416 (VEGF-R2) and A7R (NP-1). Apoptosis was then induced by the integrin inhibit…
