CareLit Fachartikel

Genetic targeting of Clara cells using a novel knock-in strategy

M Szibor, I Salwig, T Braun · Pneumologie · 2012 · Heft 05

Dokument
1171541
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
M Szibor, I Salwig, T Braun
Ausgabe
Heft 05 / 2012
Seiten
–
Erschienen: 2012-05-31 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0032-1315549

Zusammenfassung

Clara cells are a subtype of lung epithelial cells lining the bronchioles. Their proposed function is to protect the bronchiolar epithelium by (i) secreting factors, including the Clara cell secretory protein (CCSP), (ii) detoxifying harmful substances via cytochrome P450 enzymes and (iii) acting as progenitor cell during lung regeneration after injury. To study Clara cells in vivo, several attempts have been made using a variety of CCSP transgenic and knock-in approaches. Many, if not all, of the transgenic models suffer from ectopic marker expression mainly due to xenogeneic promoter usage or random cassette i…

Schlagworte

Bronchioles Cytochrome Allele Codon After Pneumologie