Nestin protein expression is an independent prognostic marker in ependymoma and discriminates WHO II ependymoma with poor outcome
T Milde, T Hielscher, H Witt, M Kool, SC Mack, HE Deubzer, I Oehme, M Lodrini, A Benner, MD Taylor, A von Deimling, AE Kulozik, SM Pfister, O Witt, A Korshunov · Klinische Pädiatrie · 2012 · Heft 11
Bibliografische Angaben
Zusammenfassung
We have previously shown that the ependymoma cancer stem cell model DKFZ-EP1NS recapitulate ependymoma tumorigenesis at the histological, molecular and clinical level in an orthotopic murine model. EP1NS cells are characterized by a high expression of the neuronal stem cell marker nestin and a stem cell expression signature. We have therefore examined nestin expression in a large cohort of 379 ependymoma primary tumors. High protein expression of nestin, as assessed by immunohistochemistry, is associated with poor prognosis. Most importantly, nestin separates grade II ependymomas into two groups with distinct su…
