Impact of genetic SLC28 transporter and ITPA variants on ribavirin serum level, hemoglobin drop and therapeutic response in patients with HCV infection
M Rau, F Stickel, S Russmann, M Weisskopf, J Schmitt, MT Dill, JF Dufour, D Moradpour, D Semela, B Müllhaupt, A Geier · Zeitschrift für Gastroenterologie · 2012 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background: Treatment of chronic hepatitis C is evolving, and DAAs are now added to Peg-INF-α and RBV for the treatment of HCV GT 1 infection. DAAs cause side effects and can even worsen RBV induced hemolytic anemia. Therefore, identifying host genetic determinants of RBV bioavailability and therapeutic efficacy will remain crucial for individualized treatment. Recent data showed associations between RBV induced hemolytic anemia and genetic polymorphisms of CNT3 (encoded by SLC28A3) and ITPA. Aim: To analyze the association of genetic variants of SLC28 transporters and ITPA with RBV induced hemolytic anemia and…
