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Tbx3 directs cell fate decision towards mesendoderm, pancreas and liver in mouse embryonic stem cells

A Kleger, C Weidgang, PR Tata, M Müller, HR Schöler, T Seufferlein, S Liebau · Zeitschrift für Gastroenterologie · 2012 · Heft 08

Dokument
1171749
CareLit-ID
Jahr
2012
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
A Kleger, C Weidgang, PR Tata, M Müller, HR Schöler, T Seufferlein, S Liebau
Ausgabe
Heft 08 / 2012
Seiten
–
Erschienen: 2012-08-22 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0032-1323939

Zusammenfassung

Pluripotency depends on networks of key transcriptional regulators. Recent reports demonstrate additional functions of pluripotency-associated factors during early lineage commitment. The T-box transcription factor Tbx3 has been implicated in the regulation of embryonic stem cell (ESC) self-renewal and pluripotency. In this study, we demonstrate previously unappreciated roles of Tbx3 for the specification of mesendoderm. Tbx3 is dynamically expressed in murine embryos and in differentiating ESCs, concomitant with specification-onset of the mesendoderm lineages. Transcriptional profiling of differentiating ESCs d…

Schlagworte

Mesendoderm Specification Towards Pancreas Liver Lineage Embryonic Pluripotency Transcriptional Demonstrate Functions Factors Zeitschrift für Gastroenterologie