Effects of pre-treatment with bezafibrate followed by standard of care in treatment-naive patients with chronic hepatitis C genotype 1 infection and elevated GGT levels
A Böhlig, V Knop, M Biermer, R Somasundaram, H Hinrichsen, R Heyne, B Möller, B Ruf, U Spengler, R Link, A Herrmann, P Malfertheiner, AW Lohse, E Herrmann, S Zeuzem, R Schäfer, T Berg · Zeitschrift für Gastroenterologie · 2012 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background/Aims: Only 50% of patients with chronic hepatitis C genotype 1 infection (HCV1) respond to peginterferon-alpha2a and ribavirin (PR). Previous studies showed that the levels of GGT correlate with nonresponsiveness to treatment. The aim of this randomized, controlled, double-blind trial was to examine if a pre-treatment reduction of GGT levels is capable of increasing response to treatment of patients with HCV type 1 infection measured by early viral kinetics including rapid and early virologic response patterns (RVR and cEVR) as compared to pre-treatment with placebo. Additionally, the effect of GGT le…
