STAT3 is a potential molecular target to sensitize colorectal cancer cells to chemoradiotherapy
M Grade, M Spitzner, B Roesler, C Bielfeld, G Emons, J Gaedcke, M Rave-Fränk, T Beißbarth, M Ghadimi · Zeitschrift für Gastroenterologie · 2012 · Heft 08
Bibliografische Angaben
Zusammenfassung
Aims: Resistance to preoperative chemoradiotherapy represents a major clinical problem in the treatment of patients with locally advanced rectal cancer. Therefore, the identification of molecular biomarkers that differentiate responsive and resistant tumors is exceedingly important, because this may lead to the identification of novel molecular targets whose modification could be harnessed to sensitize a priori resistant tumors to multimodal treatment. Materials/methods: We recently established an in vitro model for 5-FU based chemoradiotherapy, and correlated differences in treatment sensitivity of 12 colorecta…
