GNAS Codon 201 mutations are uncommon in Intraductal Papillary Neoplasms of the Bile Duct
H Matthaei, J Wu, M Dal Molin, M Debeljak, P Lingohr, N Katabi, DS Klimstra, NV Adsay, JR Eshleman, RD Schulick, KW Kinzler, B Vogelstein, RH Hruban, A Maitra · Zeitschrift für Gastroenterologie · 2012 · Heft 08
Bibliografische Angaben
Zusammenfassung
Aims: Activating point mutations of GNAS at codon 201 have recently been detected in approximately two-thirds of Intraductal Papillary Mucinous Neoplasms (IPMNs) of the pancreas. Intraductal papillary neoplasms of the bile ducts (IPNBs) morphologically resemble pancreatic IPMNs. Thus, we sought to assess the mutational status of GNAS at codon 201 in IPNBs. Methods: Thirty-four patients from three institutions were included and DNA from microdissected IPNBs was subjected to a sensitive PCR/ligation method for the detection of GNAS mutations at codon 201 and of KRAS mutations at codon 12. Mutational status was com…
