Epithelial-mesenchymal transition in ampullary cancer

Aims: Ampullary cancer is a relatively rare disease and can frequently be treated by surgical resection. There are two main subtypes, intestinal and pancreatobiliary. ZEB1 is a regulator of epithelial-mesenchymal transition (EMT). Materials and methods: We studied the occurrence and mechanisms of EMT in ampullary carcinoma using immuno-histochemical analysis from human tissue samples and two established human ampullary carcinoma cell lines. Results: Immunohistochemical (IHC) analysis of human ampullary cancer tissue showed lymph node metastasis to be associated with tumor budding and loss of CDX2 expression, ass…