Ferroportin-1 behaves as a negative acute phase protein in rat liver

Liver is the central organ of iron metabolism. During acute-phase-response (APR) serum-iron-concentration rapidly decreases. Current study aimed to compare the changes of iron-transport-protein ferroportin-1-(Fpn-1) and of other iron-import-proteins after experimental tissue damage induced by injecting turpentine-oil-(TO) in hind-limbs of rats and mice. Serum and spleen iron-concentration decreased with an increase in total liver, cytoplasmic and nuclear iron-concentration. In liver, mRNA-amount of ferroportin-1-(Fpn-1)-, ferroportin-1-a-(Fpn-1a), ferroportin-1-b-(Fpn-1b), HFE-, hemojuvelin-(HJV)- and hephastin-…