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House dust mite-induced ATP release plays a role in the innate immunological response and barrier dysfunction of airway epithelium

S Post, M Nawijn, A van Oosterhout, I Heijink · Pneumologie · 2012 · Heft 11

Dokument
1171943
CareLit-ID
Jahr
2012
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
S Post, M Nawijn, A van Oosterhout, I Heijink
Ausgabe
Heft 11 / 2012
Seiten
–
Erschienen: 2012-11-13 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0032-1329799

Zusammenfassung

Background: House dust mite (HDM) affects both the barrier and the innate immune functions of the airway epithelium. The release of ATP upon HDM administration has been shown to be critically required for allergic sensitization, airway remodeling and eosinophilic inflammation in a mouse model. Objective: We sought to determine the role of ATP release in the HDM-induced altered barrier function and innate immune responses of airway epithelium. Methods: We investigated the effect of HDM on accumulation of intracellular Ca2+ levels ([Ca2+]i) (Ca2+ influx assay), barrier function (ECIS) and CCL20 release (ELISA) in…

Schlagworte

Asthma Airway Remodeling Apyrase Calcium Calpain After Pneumologie