Differenzial analysis of antioxidative capacities in the alveolar compartment of diffuse parenchymal lung disorders and diseased controls

Diffuse parenchymal lung disorders (DPLDs) are a heterogeneous group of rare entities including granulomatous DPLDs like sarcoidosis, and idiopathic interstitial pneumonias like non specific interstitial pneumonia (NSIP) and usual interstitial pneumonia (UIP). Common hallmarks of these entities are inflammation and fibrosis of lung interstitium and small airways. In the normal lung the antioxidant defense system protects the alveolar compartment from damaging effects of environmental oxidative influence. In DPLDs the regulation of antioxidants are thought to be disturbed. Searching for biomarkers to be used as s…