Type I interferons boost pulmonary granuloma formation in the TDM mouse model via Ly6C+ monocytes recruitment

Introduction: Sarcoidosis is a systemic disease and is most frequently characterised by compartmentalized TH1 inflammation and the generation of non-caseating, epitheloid cell granulomas. It is well known that recombinant interferon-alpha treatment can induce sarcoidosis. There is mounting evidence that products derived from Mycobacteria and Propionibacteria are involved in the pathogenesis of sarcoidosis. Several studies described that intravenous injection of mycobacterial cord factor (TDM) results in well defined pulmonary granuloma formation in mice. Rationale: The aim of this study is to analyze the effect…