Crosstalk between IKKγ/Nemo and the Jnk genes in the progression from hepatitis to hepatocellular carcinoma
FJ Cubero, G Zhao, YA Nevzorova, M Hatting, N Hermanns, F Schäfer, O Drvarov, N Gaßler, C Liedtke, C Trautwein · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and Aim: Increased hepatocyte damage is a common mechanism observed in NAFLD patients which contributes to hepatitis and development of hepatocellular carcinoma (HCC). During the progression of liver injury, the crosstalk between the regulatory subunit of NF-κB, IKKγ/Nemo and the JNK genes might be a major determinant in the fate of hepatocytes towards survival or apoptosis. Thus, we investigated the interaction between Jnk1 and Jnk2 and Nemo during chronic liver disease. Methods: We generated hepatocyte-specific Nemo knockout mice (NemoΔhepa) and crossed them with Jnk1-/- (Jnk1-/-/NemoΔhepa) and Jnk2…
