Hepatocyte specific deletion of Mesenchymal-epithelial transition factor (c-Met) leads to the development of severe non-alcoholic-steatohepatitis (NASH) in a murine NASH model
F Schumacher, M Hatting, N Gaßler, MV Boekschoten, M Müller, KL Streetz, C Trautwein, DC Kroy · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: One of the fastest growing medical problems in industrial countries is the metabolic syndrome including non-alcoholic-fatty-liver disease (NAFLD). The spectrum of NAFLD includes NASH. NASH is characterized by hepatic fat accumulation leading to an increase of oxidative stress and apoptosis resulting in severe inflammation and finally liver cirrhosis and hepatocellular carcinoma. As a consequence, NASH-related liver transplantation rates are increasing. HGF (hepatocyte growth factor)/mesenchymal-epithelial transition factor (c-Met) receptor is known to be anti-apoptotic in hepatocytes. Moreover, apopt…
