Human in vitro model of steatosis hepatis and the influence of anti-lipidemic drugs on energy metabolism in steatotic hepatocytes

Non-alcoholic fatty liver disease (NAFLD) caused by an excessive caloric intake is already the most common chronic liver disease in western countries. Therefore fatty livers have become pivotal in surgical interventions and organ transplantation. Postoperatively, this results in decreased liver regeneration as well as reduced detoxification capacity and may lead to all degrees of hepatic failure. Therefore, there is need for fast clearance of liver fat from a surgical point of view. Epidemiologic studies suggest that Genistein (GEN) has a beneficial influence on lipid metabolism. Our aim was to establish a human…