miR-125b regulates the Lin-28/IGF-II axis during hepatocellular carcinogenesis
N Elfimova, N Winkel, M Quasdorff, A Noetel, L Zhang, W Amer, U Protzer, HP Dienes, U Drebber, M Odenthal · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: MicroRNA (miRNA), involved in posttranscriptional regulation of gene expression, play an important role in cell proliferation and differentiation. Previous data have shown that miR-125b expression was shown to be involved in liver carcinogenesis. Here, we focused on the role of miR-125b in development of hepatocellular carcinoma (HCC). Methodology: A Cre-expressing adenoviral vector was applied to Alb-SV40 T-Ag transgenic mice in order to induce liver carcinogenesis. Expression levels of miR-125b were determined at different time points of murine tumorogenesis and in human hepatoma cell lines. Putati…
