An oncolytic measles vaccine virus armed with a suicide gene eliminates human hepatoma cells independently of apoptosis
J Lampe, S Bossow, T Weiland, IP Smirnow, R Lehmann, WM Neubert, M Bitzer, UM Lauer · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and Aims: Due to late diagnosis and a pronounced chemoresistance, most patients with hepatocellular carcinoma (HCC) have an overall poor prognosis. Oncolytic Measles vaccine viruses (MeV) have been shown to possess anti-tumor properties and their efficacy has been enhanced by arming with suicide genes. Here, we sought to test suicide gene-armed oncolytic MeV for the virotherapeutic treatment of HCC and to address the hypothesis that apoptosis deficiencies are not relevant to the oncolytic effector mechanisms of our protoypic oncolytic MeV vectors. Methods: Oncolytic MeV armed with the suicide gene Sup…
