CareLit Fachartikel
Regulation of pro-angiogenic factors in two mouse models of HCC – contribution of carbon monoxide
JH Wulf, R Barikbin, J Schildgen, G Sass, G Tiegs · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Dokument
1172295
CareLit-ID
Jahr
2013
Publikation
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Zusammenfassung
Background and Aims: Heme oxygenase 1 (HO-1) has been shown to be over-expressed in tumors and to protect tumors from apoptosis. The HO-1 product carbon monoxide (CO) has been identified as a mediator of this protection. Signaling pathways and mediators of CO-induced cytoprotection have not yet been identified, but could serve as potential targets for tumor therapy. Angiogenesis has been shown to play a crucial role in the progression of hepatocellular carcinoma and a wide variety of chronic liver diseases. It has been shown that CO is able to induce expression of the pro-angiogenic vascular endothelial growth f…
Schlagworte
Tumor
Angiopoietins
Angiopoietin 1
Angiopoietin-1
Apoptosis
Chloride
After
Zeitschrift für Gastroenterologie
