Continuous Toll-like receptor 3 activation in primary human hepatocytes, mimicking chronic hepatitis C infection, leads to hyper-responsiveness to poly I:C in vitro
R Broering, M Lutterbeck, K Kleinehr, M Trippler, A Paul, G Gerken, JF Schlaak · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aim: Chronic hepatitis C infection is associated with elevated expression of interferon sensitive genes (ISGs) in the liver, which should limit viral replication, but correlates with the non-response to interferon (IFN) based therapies. Recent data suggested that type-III interferons (IFN; Interleukin (IL-) 28A, -28B and 29) may play an important role in the defense of HCV. Aim of this study was to investigate the Toll-like receptor (TLR) signaling in primary human hepatocytes and the capacity of these cells to control HCV replication. Methods: PHH were isolated from liver samples obtained after tumor resection…
