CareLit Fachartikel
Interferon standard therapy alters neuronal physiology in HCV patients
C Hoyo-Becerra, A Huebener, G Gerken, JF Schlaak · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Dokument
1172298
CareLit-ID
Jahr
2013
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Zusammenfassung
Background: Interferon-alpha (IFN) based therapy is the current standard therapy used for the treatment of chronic hepatitis C. Interestingly, IFN-mediated depressive side effects are much more frequent in HCV patients compared to HBV patients or individuals with malignant melanoma that receive this therapy. The physiological mechanisms underlying this hyper-responsiveness of HCV patients are still unknown. Therefore, we have analyzed the alterations prompted by IFN and poly(I:C) (which would mimic the presence of a HCV replicative intermediates) on crucial neuronal physiologic parameters related to the developm…
Schlagworte
Apoptosis
Depression
Dendrites
Antibodies
Axons
Hepatitis
Zeitschrift für Gastroenterologie
