CareLit Fachartikel

A potential role of the proteoglycan biglycan in a murine model of allergic airway inflammation

A Zech, T Müller, S Cicko, K Baudiß, K Ayata, M Braun, A Meyer, M Idzko · Pneumologie · 2013 · Heft 02

Dokument
1172378
CareLit-ID
Jahr
2013
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
A Zech, T Müller, S Cicko, K Baudiß, K Ayata, M Braun, A Meyer, M Idzko
Ausgabe
Heft 02 / 2013
Seiten
–
Erschienen: 2013-02-27 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0033-1334719

Zusammenfassung

Background: The extracellular matrix component biglycan (Bgn), a small leucine-rich proteoglycan (SLRP), is known to act as damage-associated pattern (DAMP). Following secretion by activated macrophages or proteolytic digestion the soluble biglycan is capable of binding to TLR2, TLR4 and P2X7 thereby triggering downstream signalling events leading to an increased production of pro-inflammatory cytokines like IL-1ß, TNF-alpha as well as the chemotractant CXCL13. Purpose: Due to its role in inflammation we suggested that Bgn deficiency influences the development of allergen-induced asthma. Method: Bgn-/- and Bgn+/…

Schlagworte

Biglycan Asthma Bronchoalveolar Lavage Fluid Bronchoalveolar Lavage Dendritic Cells Cytokines Aerosols Cytokine After Pneumologie