CareLit Fachartikel
The role of HMGB1 in diabetic cardiomyopathy
C Volz, P Heger, D Laohachewin, F Lasitschka, Z Kaya, HA Katus, M Andrassy · Diabetologie und Stoffwechsel · 2013 · Heft 04
Dokument
1172529
CareLit-ID
Jahr
2013
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Aims: Increasing evidence has established causative links between chronic inflammation and insulin resistance and type 2 diabetes mellitus. The aim of this study is to evaluate the role of High-mobility group box 1 (HMGB1), a potent innate “danger signal”, in the induction and propagation of a chronic inflammatory response in an animal model of diet induced obesity/type 2 diabetes (DIO) alone and in combination with chronic pressure overload induced hypertrophy after transverse aortic constriction (TAC). Results: Diabetic environment alone led to the activation of isolated cardiomyocytes, cardiac fibroblasts and…
Schlagworte
Diabetes Mellitus
Apoptosis
Obesity
Diet
Lead
After
Diabetologie und Stoffwechsel
