Missing evidence of alternative c-Cbl activation in human fat cells

Aim: Obesity is a major risk factor for developing insulin resistance. Hypertrophy of adipocytes is considered to be a significant predictor of this situation. Previous studies have shown that besides the classical IRS/AKT-pathway the alternative activation of CAP/cbl might be responsible for glucose uptake, at least in rodent cell lines. However, no data are available taking cell size into account. This study was therefore designed to measure insulin driven signalling in small and hypertrophied adipocytes. Materials and methods: Isolated subcutaneous adipocytes were obtained from healthy subjects undergoing ele…