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Continuous but not intermittent long-term exposure to the tyrosine kinase inhibitor (TKI) dasatinib causes cardiac failure in juvenile rats

P Geidel, JT Tauer, N Steinbronn, R Jung, E Bonifacio, I Leuschner, RH Strasser, M Suttorp · Klinische Pädiatrie · 2013 · Heft 05

Dokument
1172595
CareLit-ID
Jahr
2013
Publikation
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
P Geidel, JT Tauer, N Steinbronn, R Jung, E Bonifacio, I Leuschner, RH Strasser, M Suttorp
Ausgabe
Heft 05 / 2013
Seiten
–
Erschienen: 2013-05-22 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0033-1343629

Zusammenfassung

* these authors contributed equally to the work Background: TKI treatment can result in cardiac failure as these drugs exert off-target effects via so far ill-defined mechanisms. Long-term exposure is of great concern in pediatric patients which may require life-long treatment for diseases like chronic myeloid leukemia. We here investigated the impact of prolonged dasatinib exposure on the growing heart in juvenile rodents. Methods: 4-week old male Wistar rats were exposed via the drinking water to dasatinib at a standard dose (cohort S: 50µM) and a high dose (cohort H: 100µM) continuously, and also at the high…

Schlagworte

Dasatinib After Weaning Blood Work Klinische Pädiatrie