Loss of ABCG2 leads to right ventricular diastolic dysfunction in pulmonary hypertension

Introduction: The molecular pathways leading to right ventricular dysfunction in pulmonary hypertension (PH) are poorly understood. ABCG2 is a cell membrane transporter with effective drug transport ability protecting against intracellularly accumulated toxic metabolites. It provides cell survival advantage under hypoxic conditions and oxidative stress. Aim: To investigate the contribution of ABCG2 transporter on right ventricular (RV) function in the hypoxia induced PH mouse model. Methods: Wild type (n≥9) and ABCG2 knockout (n≥9) mice were exposed to 10% hypoxia for 5 weeks. Haemodynamic parameters – including…