Myofibroblast-derived secreted frizzled-related protein 1 (SFRP1) can inhibit colorectal carcinoma field cancerization
G Valcz, V Patai, I Füri, A Kalmár, B Péterfia, F Sipos, T Krenács, N Nagy, G Barna, B Wichmann, B Molnár, Z Tulassay · Zeitschrift für Gastroenterologie · 2013 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Despite frequent mutations of canonical Wnt signal in colorectal cancer (CRC), the α-SMA+ myofibroblast-derived interellular Wnt regulator SFRP1 may play a crucial role in the inhibiton of autocrine Wnt loop in epithelial cells. This effect may appear in the genetically and epigenetically altered, but histologically normal adjacent tumor (NAT) areas and inhibit field cancerization. Aims: We compared the SFRP1 protein expression and methylation patterns of SMA+ myofbroblasts in NAT and CRC areas. Our further aim was to demonstrate that the recombinant SFRP1 protein (as modell of myofbroblast origin) m…
