FUT2 genotype is a risk factor for biliary candida infections and dominant stenosis in primary sclerosing cholangitis
C Rupp, K Friedrich, JR Hov, A Wannhoff, K Bode, KH Weiss, P Sauer, TH Karlsen, W Stremmel, DN Gotthardt · Zeitschrift für Gastroenterologie · 2013 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background and aims: A recent genome-wide association study (GWAS) identified FUT2 secretor status and genotype defined by the single nucleotide polymorphism (SNP) rs601338 as a potential risk factor in primary sclerosing cholangitis (PSC) that significantly influences biliary bacterial composition. We analyzed the impact of FUT2 genotype on clinical significant parameters, including endoscopic finding and fungal infections. Methods: We analyzed 215 PSC patients that were treated at our tertiary care center with regard to their FUT2 genotype. ERCs and bile culture were analyzed. During ERC 639 biliary cultures w…
